This more detailed timeline of cognitive functioning, in combination with future research, can possibly be contributing in informing patients and caregivers what to expect after awake brain tumor surgery.Īwake brain tumor surgery is a safe and feasible procedure to prevent neurological deficits. The timeline of cognitive functioning after awake tumor surgery appeared overall stable in the early and late postoperative phase, except for inhibition, which is more difficult in the first days after awake brain tumor surgery. However, in the following months after surgery, they returned to their preoperative level. Directly after surgery, patients were significantly slower on this task. Overall, no significant differences were found between preoperative cognitive functioning, early postoperative cognitive functioning, and late postoperative cognitive functioning, except for performances on the inhibition task. We performed a Friedman ANOVA to analyze on group level. The cognitive screener included tests for object naming, reading, attention span, working memory, inhibition, inhibition/switching, and visuoperception. Cognitive functioning was measured by means of a broad cognitive screener preoperatively, days after surgery and months after surgery in patients who underwent awake brain tumor surgery with cognitive monitoring. Thirty-seven patients were included in this study. A more detailed timeline will be helpful in informing candidates for surgery about what to expect regarding their cognitive functioning. The aim of this study is to gain understanding of the development of possible postoperative cognitive deficits after awake brain tumor surgery in patients with suspected gliomas, by comparing preoperative, early postoperative, and late postoperative functioning. Zantac, Tagamet, Reglan, Benemid, Probalan, Compazine, Phenergan, quinidine, selegiline, verapamil, and any other medication with a known interaction) will also be excluded.The purpose of awake brain tumor surgery is to maximize the resection of the tumor and to minimize the risk of neurological and cognitive impairments. Subjects taking any medications that are known to interact with pramipexole (i.e.In addition, patients taking topiramate, tricyclic antidepressants, or anticholinergic medications that are known to impact cognition will be excluded from participation. The use of benzodiazepines, sedatives, or sleeping pills, within 6 hours of neurocognitive testing will not be allowed.Subjects taking prescription or over-the counter medications may also be excluded if these medications have been shown to impact cognition (i.e.Subjects taking clozapine will be excluded due to it's potential overlapping mechanisms of action with pramipexole.To help control for medication effects on cognition, we plan to limit the types of medications allowed by excluding certain medications with a known impact on cognitive performance. While medication status is an important consideration in any study of bipolar disorder, the exclusion of patients taking any medication is not practical, given the high prevalence of combination pharmacotherapy for bipolar disorder. Any subject with an active, unstable medical problem that may interfere with cognition will be excluded based on the investigator's judgment.Moreover, subjects with rapid-cycling during the past year will be excluded (based on SCID).Subjects with a DSM-IV diagnosis of current or recent substance abuse or dependence (in the previous 1 month) will be excluded.Subjects with a history of central nervous system (CNS) trauma, neurological disorder, Attention Deficit Hyperactivity Disorder (ADHD), or learning disability will be excluded.lithium, carbamazepine, valproate, lamotrigine). All subjects must be taking a standard mood stabilizer at a stable therapeutic dose (i.e.Subjects must also meet criteria for euthymia described above.Subjects between 18 and 65 years of age, who meet Diagnostic and Statistical Manual of Mental Disorders, 4th edition (DSM-IV) criteria for BPD I or II (by SCID) and confirmed in the diagnostic consensus conference will be included. ![]() Why Should I Register and Submit Results?.
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